Deficiencies in Complex I subunits of the respiratory chain in Parkinson's disease
β Scribed by Yoshikuni Mizuno; Shigeo Ohta; Masashi Tanaka; Shinzaburo Takamiya; Keiji Suzuki; Takeshi Sato; Hiroshi Oya; Takayuki Ozawa; Yasuo Kagawa
- Book ID
- 115761726
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 992 KB
- Volume
- 163
- Category
- Article
- ISSN
- 0006-291X
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π SIMILAR VOLUMES
There is evidence for a 37% deficiency of complex I activity in Parkinson's disease (PD), which appears to be specific for PD amongst parkinsonian syndromes and selective for the substantia nigra within the central nervous system. Rat studies have shown that, in the context of a normal nigrostriatal
## Abstract Reports on mitochondrial respiratory chain (MRC) complex I (CI) dysfunction in the substantia nigra in Parkinson's disease (PD) support the oxidative stress hypothesis in the neuropathogenesis of PD. Studies in peripheral tissue have found variable decreased CI and occasionally other co