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Deficiencies in Complex I subunits of the respiratory chain in Parkinson's disease

✍ Scribed by Yoshikuni Mizuno; Shigeo Ohta; Masashi Tanaka; Shinzaburo Takamiya; Keiji Suzuki; Takeshi Sato; Hiroshi Oya; Takayuki Ozawa; Yasuo Kagawa


Book ID
115761726
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
992 KB
Volume
163
Category
Article
ISSN
0006-291X

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## Abstract Reports on mitochondrial respiratory chain (MRC) complex I (CI) dysfunction in the substantia nigra in Parkinson's disease (PD) support the oxidative stress hypothesis in the neuropathogenesis of PD. Studies in peripheral tissue have found variable decreased CI and occasionally other co