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Analyzing protein–protein interactions in cell membranes

✍ Scribed by Anja Nohe; Nils O. Petersen

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
287 KB
Volume
26
Category
Article
ISSN
0265-9247

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✦ Synopsis

Abstract

Interactions among membrane proteins regulate numerous cellular processes, including cell growth, cell differentiation and apoptosis. We need to understand which proteins interact, where they interact and to which extent they interact. This article describes a set of novel approaches to measure, on the surface of living cells, the number of clusters of proteins, the number of proteins per cluster, the number of clusters or membrane domains that contain pairs of interacting proteins and the fraction of one protein species that interacts with another protein within these domains. These data can then be interpreted in terms of the function of the protein‐protein interactions. BioEssays 26:196–203, 2004. © 2004 Wiley Periodicals, Inc.

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