Analytical Methods for Food Authentication, edited by P. R. Ashurst and M. J. Dennis, Blackie Academic & Professional, London, 1998. No. of pages x+350, price £79.00. ISBN 0 7514 0426 8

✍ Scribed by Ross Aylott

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 53 KB
• Volume: 13
• Category: Article
• ISSN: 0882-5734
• DOI: 10.1002/(sici)1099-1026(199811/12)13:6<424::aid-ffj773>3.0.co;2-u

✦ Synopsis

I reviewed the ®rst volume of this series for Flavour and Fragrance Journal, 8, 123 (1993) when many of the compounds discussed were related to those used as ¯avours or fragrances. This second volume has a much larger emphasis on chiral drugs. Indeed, in his Introduction (10 pp.) J. Crosby says that the needs of the pharmaceutical industry are the major driving force for development of the manufacture of optically active compounds. He goes on to review the advances made since the ®rst volume. The second chapter discusses Chiral Drugs: Regulatory Aspects' (8 pp.) while the third (21 pp.) reviews Production Methods for Chiral Non-steroidal Anti-in¯ammatory Profen Drugs'. The fourth chapter (37 pp.) deals with the `Synthesis of Enantiomerically Pure Nucleosides' (related to anti-viral drugs).

The second section on Physical Methods and Classical Resolution' is of more general interest. The four chapters discuss Rational Design in Resolutions' (18 pp.), Resolution versus Stereoselective Synthesis in Drug Development: Some Case Histories' (20 pp.), Crystal Science Techniques in the Manufacture of Chiral Compounds' (38 pp.) and Membrane Separations in the Production of Optically Pure Compounds' (24 pp.). The third section on Biological Methods and Chiral Pool Syntheses' again concentrates on drug intermediates in four of the six chapters. The others deal with the Synthesis and Applications of Chiral Liquid Crystals' and Bio-transformation in the Production of L-Carnitine'.