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Analysis of tricyclic antidepressants in human plasma by GLC-chemical-ionization mass spectrometry with selected ion monitoring

✍ Scribed by Rand G. Jenkins; Robert O. Friedel

Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
832 KB
Volume
67
Category
Article
ISSN
0022-3549

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✦ Synopsis

A method is described for the analysis of amitriptyline, doxepin, imipramine, nortriptyline, desmethyldoxepin, desipramine, and protriptyline in human plasma utlizing GLC-chemical-ionization mass spectrometry with selected ion monitoring. The assay is highly specific and is quantitative to at least 1 ng/ml with a standard error typically less than 5%. Representative concentrations of the parent compounds and their monodemethylated metabolites, as meeasured in plasma samples from patients under treatment with tertiary amine tricyclic antidepressants, are given.

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