✦ LIBER ✦

Analysis of translocations that involve the NUP98 gene in patients with 11p15 chromosomal rearrangements

✍ Scribed by Yuri N. Kobzev; Jose Martinez-Climent; Sanggyu Lee; Jianjun Chen; Janet D. Rowley

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 458 KB
Volume: 41
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.20092

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The NUP98 gene has been reported to be fused with at least 15 partner genes in leukemias with 11p15 translocations. We report the results of screening of cases with cytogenetically documented rearrangements of 11p15 and the subsequent identification of involvement of NUP98 and its partner genes. We identified 49 samples from 46 hematology patients with 11p15 (including a few with 11p14) abnormalities, and using fluorescence in situ hybridization (FISH), we found that NUP98 was disrupted in 7 cases. With the use of gene‐specific FISH probes, in 6 cases, we identified the partner genes, which were PRRX1 (PMX1; in 2 cases), HOXD13, RAP1GDS1, HOXC13, and TOP1. In the 3 cases for which RNA was available, RT‐PCR was performed, which confirmed the FISH results and identified the location of the breakpoints in patient cDNA. Our data confirm the previous findings that NUP98 is a recurrent target in various types of leukemia. © 2004 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

11p15 translocations involving the NUP98

11p15 translocations involving the NUP98 gene in childhood therapy-related acute myeloid leukemia/myelodysplastic syndrome

✍ Mayumi Nishiyama; Yasuhito Arai; Yukiko Tsunematsu; Hirofumi Kobayashi; Keiko As 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 187 KB 👁 1 views

In a survey of childhood therapy-related acute myeloid leukemia/myelodysplastic syndrome (t-AML/MDS) in Japan, we found 11p15 translocations in 5 (6%) of 81 children with t-AML/MDS. t(11;17)(p15;q21), t(11;12)(p15;q13), t(7;11)(p15;p15), inv(11)(p15q22), and add(11)(p15) were each found in one patie

The chromosome translocation t(7;11)(p15

The chromosome translocation t(7;11)(p15;p15) in acute myeloid leukemia results in fusion of the NUP98 gene with a HOXA cluster gene, HOXA13, but not HOXA9

✍ Takeshi Taketani; Tomohiko Taki; Ryoichi Ono; Yukio Kobayashi; Kohmei Ida; Yasuh 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 211 KB

The nucleoporin gene NUP98 has been reported to be fused to 9 partner genes in hematologic malignancies with 11p15 translocations. The NUP98-HOXA9 fusion gene has been identified in acute myeloid leukemia (AML) and chronic myelogenous leukemia with t(7;11)(p15;p15). We report here a novel NUP98 part

Fusion of the NUP98 gene and the homeobo

Fusion of the NUP98 gene and the homeobox gene HOXC13 in acute myeloid leukemia with t(11;12)(p15;q13)

✍ Ioannis Panagopoulos; Margareth Isaksson; Rolf Billström; Bodil Strömbeck; Felix 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 692 KB

## Abstract The __NUP98__ gene at 11p15 is known to be fused to __DDX10, HOXA9, HOXA11, HOXA13, HOXD11, HOXD13, LEDGF__, __NSD1, NSD3, PMX1__, __RAP1GDS1__, and __TOP1__ in various hematologic malignancies. The common theme in all __NUP98__ chimeras is a transcript consisting of the 5′ part of __NU

Human homeobox gene HOXC13 is the partne

Human homeobox gene HOXC13 is the partner of NUP98 in adult acute myeloid leukemia with t(11;12)(p15;q13)

✍ Roberta La Starza; Maurizio Trubia; Barbara Crescenzi; Caterina Matteucci; Massi 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 123 KB 👁 1 views

## Abstract The chimeric gene __NUP98/HOXC13__ was detected in a patient with a de novo acute myeloid leukemia and a t(11;12)(p15;q13). Fluorescence in situ hybridization with PAC1173K1 identified the breakpoint on 11p15, indicating that the __NUP98__ gene was involved in the translocation. At 12q1

Rearrangement of the MOZ gene in pediatr

Rearrangement of the MOZ gene in pediatric therapy-related myelodysplastic syndrome with a novel chromosomal translocation t(2;8)(p23;p11)

✍ Toshihiko Imamura; Naoki Kakazu; Shigeyoshi Hibi; Akira Morimoto; Yoko Fukushima 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 910 KB

## Abstract In this study, we examined a pediatric case of therapy‐related myelodysplastic syndrome (tMDS). The symptoms developed 17 months after treatment for acute myeloblastic leukemia (AML, M2 subtype according to the French–American–British [FAB] classification) involving a chromosome abnorma

Acute lymphoblastic leukemia in a patien

Acute lymphoblastic leukemia in a patient with Greig cephalopolysyndactyly and interstitial deletion of chromosome 7 del(7)(p11.2 p14) involving the GLI3 and ZNFN1A1 genes

✍ Roberto Mendoza-Londono; Catherine D. Kashork; Lisa G. Shaffer; Robert Krance; S 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 160 KB 👁 1 views

## Abstract Greig cephalopolysyndactyly (GCPS; OMIM 175700) is an autosomal dominant condition caused by mutations of the gene __GLI3__, located on 7p13. To date, several cases of deletions and/or translocations involving this locus have been reported in patients with GCPS. __GLI3__ is a transcript