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Analysis of Tlr4-Mediated LPS Signal Transduction in Macrophages by Mutational Modification of the Receptor

✍ Scribed by X Du; A Poltorak; M Silva; B Beutler


Book ID
115590000
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
145 KB
Volume
25
Category
Article
ISSN
1079-9796

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## Abstract Severe injury deranges immune function and increases the risk of sepsis and multiple organ failure. Kupffer cells play a major role in mediating posttraumatic immune responses, in part via different Toll‐like receptors (TLR). Although mitogen‐activated protein kinases (MAPK) are key ele