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Analysis of three human interleukin 5 structures suggests a possible receptor binding mechanism

✍ Scribed by J.-L Verschelde; C Ampe; Y Guisez; C Oefner; J Vandekerckhove; J Tavernier


Book ID
117108836
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
750 KB
Volume
424
Category
Article
ISSN
0014-5793

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## Abstract Molecular modeling of conformational changes occurring in the transmembrane region of the complement factor 5a receptor (C5aR) during receptor activation was performed by comparing two constitutively active mutants (CAMs) of C5aR, NQ (I124N/L127Q), and F251A, to those of the wild‐type C