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Analysis of thePTENgene mutation in polyposis syndromes and sporadic gastrointestinal tumors in Japanese patients

✍ Scribed by Kenichi Negoro; Seiichi Takahashi; Yoshitaka Kinouchi; Sho Takagi; Nobuo Hiwatashi; Ryo Ichinohasama; Tooru Shimosegawa; Takayoshi Toyota


Publisher
Springer
Year
2000
Tongue
English
Weight
655 KB
Volume
43
Category
Article
ISSN
0012-3706

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Germline mutations in the tumor-suppresor APC gene are associated with hereditary familial adenomatous polyposis (FAP) and somatic mutations are common in sporadic colorectal cancer. In this study, we report the identification of three novel germline mutations: 1682-1683insA, 3252-3253insAT, 3544A>T