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Analysis of the tyrosine hydroxylase and dopamine D4 receptor genes in a Croatian sample of bipolar I and unipolar patients

✍ Scribed by Oruč, L.; Verheyen, G.R.; Furač, I.; Jakovljević, M.; Ivezić, S.; Raeymaekers, P.; Van Broeckhoven, C.

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
133 KB
Volume
74
Category
Article
ISSN
0148-7299

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✦ Synopsis

We selected 83 patients with bipolar disorder type I or unipolar recurrent major depression and 71 healthy controls for genetic analysis of the tyrosine hydroxylase and the dopamine D4 receptor gene. No significant association was found between bipolar disorder type I and unipolar recurrent major depression and the polymorphisms located near these genes. Therefore, the hypothesis that the tyrosine hydroxylase and the dopamine D4 receptor genes may be involved in the etiology of bipolar disorder and unipolar recurrent major depression is not supported in our study. Am.

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