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Analysis of the oxidative catabolism of retinoic acid in rat Dunning R3327G prostate tumors

✍ Scribed by Krekels, Marita D.W. G.; Zimmerman, Jacco; Janssens, Boudewijn; Van Ginckel, Robert; Cools, Willy; Van Hove, Carl; Coene, Marie-Claire; Wouters, Walter

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
558 KB
Volume
29
Category
Article
ISSN
0270-4137

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✦ Synopsis

We studied the enzymatic characteristics of the oxidative catabolism of retinoic acid (RA) and its inhibition by liarozole-fumarate in homogenates of rat Dunning R3327G prostate tumors. Homogenates of rat liver were used as reference material. Both tumor and liver homogenates were able to catabolize retinoic acid. HPLC analysis revealed only very polar metabolites in tumors, while in the liver both metabolites with intermediate polarity and more polar metabolites were found. Kinetic analysis of retinoic acid catabolism showed a K, of 1.7 * 0.7 FM and a V,,, of 4.2 2 4.4 pmol polar RA metabolitedmg p r o t e i h for Dunning G tumor homogenates. In liver homogenates a K, , , value of 4.3 * 0.5 p M and a V,,, value of 290 2 120 pmol polar RA metaboliteslmg proteinhr were obtained. Liarozole-fumarate inhibited retinoic acid catabolism in Dunning tumors and liver with IC,, values of 0.26 * 0.16 p M and 0.14 * 0.05, respectively. The results suggest that rat Dunning R3327G tumors are able to metabolize retinoic acid in a manner similar to that found in rat liver but with a lower metabolizing capacity.

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