Analysis of the NF2 gene in oligodendrogliomas and ependymomas
โ Scribed by M.Eva Alonso; M.Josefa Bello; Dolores Arjona; Pilar Gonzalez-Gomez; Jesus Lomas; Jose M de Campos; M.Elena Kusak; Alberto Isla; Juan A Rey
- Book ID
- 114135253
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 159 KB
- Volume
- 134
- Category
- Article
- ISSN
- 0165-4608
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## Abstract Deletions of chromosome 22 have been identified in 3 types of childhood primary brain tumor: meningiomas, rhabdoid or atypical teratoid tumors (ATT) and ependymomas. This implicates the involvement of tumor suppressor genes on chromosome 22 in the genesis of these rare tumors. One such
## Abstract Cytogenetic and/or loss of heterozygosity studies were performed on 13 ependymomas, 11 pilocytic astrocytomas, and 18 oligodendrogliomas. Loss of chromosome 22 was the most frequent genetic abnormality among the ependymomas. We found no consistent genetic abnormality in pilocytic astroc