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Analysis of the methylation status of the KCNQ1OT and H19 genes in leukocyte DNA for the diagnosis and prognosis of Beckwith–Wiedemann syndrome

✍ Scribed by Gaston, Véronique; Le Bouc, Yves; Soupre, Véronique; Burglen, Lydie; Donadieu, Jeam; Oro, Hubert; Audry, Georges; Vazquez, Marie-Paule; Gicquel, Christine


Book ID
110025133
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
279 KB
Volume
9
Category
Article
ISSN
1018-4813

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The Beckwith-Wiedemann syndrome (BWS) is an overgrowth malformation syndrome that occurs with an incidence of 1:13,700 births. There is a striking incidence of childhood tumors found in BWS patients. Various lines of investigation have localized "imprinted" genes involved in BWS and associated child