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Analysis of the Malondialdehyde−2‘- Deoxyguanosine Adduct Pyrimidopurinone in Human Leukocyte DNA by Gas Chromatography/Electron Capture/Negative Chemical Ionization/Mass Spectrometry

✍ Scribed by Rouzer, Carol A.; Chaudhary, Ajai K.; Nokubo, Munetaka; Ferguson, David M.; Reddy, G. Ramachandra; Blair, Ian A.; Marnett, Lawrence J.

Book ID
120415403
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
147 KB
Volume
10
Category
Article
ISSN
0893-228X

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## Abstract The major adduct of malondialdehyde with guanine, M~1~G, was measured in human urine from non‐smoking healthy individuals. M~1~G is a mutagenic DNA lesion and a terminal product of lipid peroxidation __in vivo__ that may be implicated in cancer related to lifestyle and diet. On the basi