✦ LIBER ✦

Analysis of the distribution of erythrocyte sodium lithium countertransport in a sample representative of the general population

✍ Scribed by Eric Boerwinkle; Stephen T. Turner; Richard Weinshilboum; Mark Johnson; Elliott Richelson; Dr. Charles F. Sing; D. C. Rao

Publisher: John Wiley and Sons
Year: 1986
Tongue: English
Weight: 929 KB
Volume: 3
Category: Article
ISSN: 0741-0395
DOI: 10.1002/gepi.1370030509

No coin nor oath required. For personal study only.

✦ Synopsis

Numerous studies of sodium-lithium countertransport (Na-Li CNT) have reported higher rates in essential hypertensives versus normotensive controls. We studied the distribution and the mode of inheritance of Na-Li CNT using a sample of 238 unrelated individuals and a sample of 245 individuals in 50 pedigrees all sampled from the population at large. The distribution of Na-Li CNT is continuous and bimodal. Our results indicate that there is a large genetic contribution to the distribution of Na-Li CNT. The hypothesis that the effect that causes bimodality is transmitted from generation to generation is supported by the fit to these data of a restricted transmission model with 72 = 0.749. We hypothesize that this deviation of 72 from its Mendelian expectation may be attributable to heterogeneity in the etiology of the bimodality in the Na-Li CNT distribution in the population at large.

📜 SIMILAR VOLUMES

Prevalence of spirometric abnormalities

Prevalence of spirometric abnormalities in a representative sample of the population of Michigan

✍ Albert Miller; Raphael Warshaw; John C. Thornton 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 840 KB

Nisoldipine blocks the increase of intra

Nisoldipine blocks the increase of intracellular free calcium-ion concentration associated with elevated sodium-lithium countertransport activity in erythrocytes in patients with NIDDM

✍ Fujita, J.; Tsuda, K.; Obayashi, H.; Fukui, I.; Ishida, H.; Seino, Y. 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 122 KB 👁 2 views

To understand the mechanism by which elevated sodium-lithium countertransport activity (SLC) associates with increased intracellular free calcium-ion concentration ([Ca 2+ ] i ), we investigated the relationship between SLC and the effects of the extracellular Ca 2+ concentration ([Ca 2+ ] o ) and a

The need for work: Jahoda's latent funct

The need for work: Jahoda's latent functions of employment in a representative sample of the German population

✍ Karsten I. Paul; Bernad Batinic 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 151 KB

## Abstract Marie Jahoda's latent deprivation model was tested with a representative sample of the German population (__N__ = 998). As expected, employees reported high levels of time structure, social contact, collective purpose, and activity not only in comparison to unemployed persons but also i

The Po River Delta epidemiological study

The Po River Delta epidemiological study: use of medicines in a general population sample of north Italy

✍ Marzia Simoni; Marzia Pedreschi; Sandra Baldacci; Francesco Pistelli; Laura Carr 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 137 KB 👁 2 views

Purpose-To provide information on the actual use of medicines in a general population sample.Methods-Information was collected in a general population sample of North Italy (1946 subjects; 938 males, 1008 females) by an interviewer-administered questionnaire.Results-Of the subjects 25.9% took habitu

Occurrence rate and genotype distributio

Occurrence rate and genotype distribution of the JC virus (JCV) in a sample from the Polish population

✍ Dariusz Kmieciak; Szymon Dębicki; Wiesław H. Trzeciak 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 89 KB

## Abstract The JC virus (JCV) is a common human virus persisting in renal tissue. In immunocompromised individuals it may reactivate and cause progressive multifocal leukoencephalopathy (PML). JCV has also been implicated in cancerogenesis, leading to various brain tumors and cancers of gastrointe

Exploring daily variations of drinking i

Exploring daily variations of drinking in the Swiss general population. A growth curve analysis

✍ Jean-Luc Heeb; Gerhard Gmel; Jürgen Rehm; Meichun Mohler-Kuo 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 175 KB

## Abstract This study aims to address the underlying trajectories of weekly individual drinking patterns by growth models and to relate differences in drinking patterns to socio‐demographic and drinking characteristics of respondents. Data came from a two‐stage stratified random subsample of 747 p