Analysis of the conformational preferences of (4R,5R)-4,5-bis(alkylcarbamoyl)-1,3-dioxolanes
✍ Scribed by Carlos Alemán; Antxon Martínez de Ilarduya; Ernest Giralt; Sebastián Muñoz-Guerra
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 642 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0040-4020
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## Abstract The synthesis of ^14^C‐labelled __cis__‐malonato[(4__R__,5__R__)‐4,5‐bis(aminomethyl)‐2‐isopropyl‐1,3‐dioxolane]platinum(II) from [1,4‐^14^C] D‐tartaric acid is described. The overall radiochemical yield of the product in a eight‐step sequence was 23.8% and radiochemical purity was 98.5
## Abstract Variable temperature ^1^H‐NMR‐study of 5‐Me‐5‐R‐1,2,3‐trithianes shows an axial preference for linear and α‐branched groups; this preference is disfavoured by β‐substitution. The Ph‐group takes exclusively the equatorial position.