Analysis of the 10q23 chromosomal region and the PTENgene in human sporadic breast carcinoma
✍ Scribed by Feilotter, H E; Coulon, V; Dorion-Bonnet, F; Duboué, B; Eng, C; Mulligan, L M; Longy, M
- Book ID
- 110000981
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 153 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0007-0920
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Cowden disease, a dominantly inherited syndrome characterized by a variety of proliferative lesions and predisposition to breast and thyroid cancer, has recently been linked to the polymorphic marker D10S215 on chromosome segment 10q23. Loss of heterozygosity in prostate cancer is linked to the same
## BACKGROUND. Frequent allelic losses on the long arm of chromosome 13 in sporadic breast carcinomas suggest that a tumor suppressor gene(s) on 13q is involved in this type of carcinoma. The presence of a familial breast carcinoma susceptibility gene, BRCA2, and the retinoblastoma susceptibility