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Analysis of pharmaceuticals and other solutes of biochemical importance by supercritical fluid chromatography

✍ Scribed by White, C. M. ;Gere, D. R. ;Boyer, D. ;Pacholec, F. ;Wong, L. K.

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 411 KB
Volume: 11
Category: Article
ISSN: 0935-6304
DOI: 10.1002/jhrc.1240110124

No coin nor oath required. For personal study only.

✦ Synopsis

The feasibility of using supercritical fluid chromatography (SFC) for analysis of polar and/or ionic analytes of interest to the pharmaceutical industry is described. Specifically, the analyses of cyclosporin (a cyclic undecapeptide), several ionophores, and a group of fat-soluble vitamins are illustrated. The separation of a group of fat-soluble vitamins is evaluated on two bonded stationary phases, DB-5 (95'/0 dimethyl-5%-diphenylpolysilox- ane) and DB-WAX (Carbowax 20M type, "bonded"). Lastly, a new restrictor technology known as a converging-diverging restrictor is described.

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