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Analysis of organic acids, amino acids, and carnitine in dogs with lipid storage myopathy

✍ Scribed by G. Diane Shelton; William L. Nyhan; Philip H. Kass; Bruce A. Barshop; Richard H. Haas

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 224 KB
Volume: 21
Category: Article
ISSN: 0148-639X
DOI: 10.1002/(sici)1097-4598(199809)21:9<1202::aid-mus13>3.0.co;2-t

No coin nor oath required. For personal study only.

✦ Synopsis

Abnormal accumulations of lipid droplets, localized predominantly in histochemical type 1 fibers, were observed in fresh frozen sections of muscle biopsies from 25 dogs with myalgia, weakness, and muscle atrophy. Compared to controls, lactic acidemia, hyperalaninemia, lactic and pyruvic aciduria, variably increased urinary excretion of carnitine esters, and muscle carnitine deficiency were present. These findings support a metabolic block in oxidative metabolism resulting in lactic acidemia in dogs with lipid storage myopathy.

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