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Analysis of mRNA in hemophilia A patients with undetectable mutations reveals normal splicing in the factor VIII gene

✍ Scribed by O. EL-MAARRI; U. HERBINIAUX; J. GRAW; J. SCHRÖDER; A. TERZIC; M. WATZKA; H. H. BRACKMANN; W. SCHRAMM; P. HANFLAND; R. SCHWAAB; C. R. MÜLLER; J. OLDENBURG


Book ID
109148804
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
219 KB
Volume
3
Category
Article
ISSN
1538-7933

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Hemophilia A is a common X-linked bleeding disorder caused by mutations in the coagulation factor VIII gene. The entire coding and essential sequences of the factor VIII gene were generated by a combination of genomic DNA amplification and long reverse transcription-polymerase chain reaction (long R