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Analysis of limb patterning in BMP-7-deficient mice

✍ Scribed by Hofmann, Clementine ;Luo, Guangbin ;Balling, Rudi ;Karsenty, Gerard

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
969 KB
Volume
19
Category
Article
ISSN
0192-253X

No coin nor oath required. For personal study only.

✦ Synopsis

Bone morp hog enetic proteins (BMPs) are polypeptide signaling molecules, belonging to the TGF-P superfamily. They were originally identified by their ability to induce ectopic bone formation, but their expression patterns in embryos suggest multiple functions. BMP-7-deficient mice show among other mesodermal and skeletal patterning defects, polydactyly in the hindlimbs [

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