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Analysis of neuronal and glial phenotypes in brains of mice deficient in leukemia inhibitory factor

✍ Scribed by Bugga, Lakshmi ;Gadient, Reto A. ;Kwan, Karen ;Stewart, Colin L. ;Patterson, Paul H.

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
450 KB
Volume
36
Category
Article
ISSN
0022-3034

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✦ Synopsis

Leukemia inhibitory factor (LIF)

lower than in the WT. The null male hippocampus can regulate the survival and differentiation of certain also displays a significant, though less marked deficit. neurons and glial cells in culture. To determine the

The number of astrocytes in the mutant hippocampus, role of this cytokine in the central nervous system in as determined by S-100 staining, is not, however, sigvivo, we examined the brains of young and adult mice nificantly different from WT. In addition, quantificain which the LIF gene was disrupted. Immunohistotion of immunohistochemical staining of female, but chemical staining of neurons for choline acetyltransnot male, mutants reveals a significant deficit in myferase, tyrosine hydroxylase, serotonin, parvalbumin, elin basic protein content in three brain regions, sugcalbindin, neuropeptide Y, vasoactive intestinal polygesting alterations in oligodendrocytes as well. Thus, peptide, and calcitonin gene-related peptide revealed while overall brain histology appears normal, the abno significant differences between null mutant and sence of LIF in vivo leads to specific, sexually dimorwild-type (WT) brains. In contrast, analysis of glial phic alterations in glial phenotype. ᭧ 1998 John Wiley & phenotypes demonstrated striking deficits in the LIF-

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