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Analysis of Lanthanide-Induced Conformational Change of the C-Terminal Domain on Centrin

โœ Scribed by Ya-Qin Zhao; Jun Yan; Li Song; Ya-Nan Feng; Ai-Hua Liang; Bin-Sheng Yang

Publisher
Springer
Year
2011
Tongue
English
Weight
476 KB
Volume
22
Category
Article
ISSN
1053-0509

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The C-terminal domain of the heterotrimeric G protein a-subunits plays a key role in selective activation of G proteins by their cognate receptors. Several C-terminal fragments of Galpha(s) (from 11 to 21 residues) were recently synthesized. The ability of these peptides to stimulate agonist binding