A LIS investigation of analogues of amiodarone containing the 3-benzoyl-2-butylbenzofuran system has been performed, utilizing the pseudo-contact shifts of all the proton and carbon nuclei in the molecules. The 13C diamagnetic shifts were removed by use of La(fod), and the pseudo-contact shifts were
The solution structure of lidocaine: Conformational analysis and NMR lanthanide-induced shifts
β Scribed by Laurine A. Laplanche; Garret Vanderkooi; Halila Jasmani; Maimunah Mat Suki
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 756 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0749-1581
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Proton lanthanide-induced shifts (LIS) were measured for Yb(fod),-dibucaine complexes in CDCl, solution. The data were used in conjunction with empirical energy calculations to determine the preferred conformations of dibucaine. The energy calculations and the LIS analysis were in agreement in showi
## Abstract Lanthanide induced shifts using Yb(fod)~3~ and Pr(fod)~3~ were used for the signal assignments of the ^13^C spectra of the 1,4βbenzodiazepines diazepam, desmethyldiazepam, prazepam and flurazepam, and for characterizing their solution conformation with respect to the substituents at Nβ1