Analysis of human T lymphocyte activation in a T cell tumor model system
β Scribed by Ulf Landegren; Jan Andersson; Hans Wigzell
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 416 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0014-2980
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## Abstract Human lymphocytes gene expression is monitored before and after PHA stimulation over 72 h, using DNA microarray technology. Results are then compared with our previous bioinformatics predictions, which identified six leader genes of highest importance in human T lymphocytes cell cycle.
Genetic engineering of human T lymphocytes to express tumor antigen-specific chimeric immune receptors is an attractive means for providing large numbers of effector cells for adoptive immunotherapy while bypassing major mechanisms of tumor escape from immune recognition. We have applied this strate