Analysis of HLA-A24-restricted peptides of carcinoembryonic antigen using a novel structure-based peptide-HLA docking algorithm
โ Scribed by Yoji Nakamura; Sachiko Tai; Chie Oshita; Akira Iizuka; Tadashi Ashizawa; Shuji Saito; Shigeki Yamaguchi; Haruhiko Kondo; Ken Yamaguchi; Yasuto Akiyama
- Book ID
- 108587023
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 799 KB
- Volume
- 102
- Category
- Article
- ISSN
- 1347-9032
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Carcinoembryonic antigen (CEA), which is expressed in several cancer types, is a potential target for specific immunotherapy. HLA-A24 is the most frequent allele among Japanese and is also frequently present in Asians and Caucasians. We tested CEA-encoded HLA-A24 binding peptides for their capacity
## Background and objectives: Using peripheral blood mononuclear cells (pbmcs) from a 10-year survivor with established human leukocyte antigen (hla)-a2(+) and mage-3(+) esophageal cancer cell line (kyse-170), we examined the induction of hla-a2-restricted and mage-3-gene-derived peptide (flwgpralv
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