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Analysis of genetic variants of the poly(ADP-ribose) polymerase-1 gene in breast cancer in French patients

โœ Scribed by Wen-Hui Cao; Xiaogan Wang; Lucien Frappart; Dominique Rigal; Zhao-Qi Wang; Yan Shen; Wei-Min Tong

Book ID
116759297
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
634 KB
Volume
632
Category
Article
ISSN
1383-5718

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## Abstract Amyloid peptide is thought to play a critical role in neuronal death in Alzheimer's disease (AD), most likely through oxidative stress. Free radicalโ€related injury leads to DNA breaks, which subsequently activates the repair enzyme poly(ADPโ€ribose) polymeraseโ€1 (PARPโ€1). In this study,