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Evaluation of the poly(ADP-ribose) polymerase gene in human stroke

✍ Scribed by Norihiro Kato; Hiroyuki Morita; Takao Sugiyama; Hiroki Kurihara; Shin-ichi Tsubaki; Toru Nabika; Kazuyuki Kitamura; Yukio Yamori; Yoshio Yazaki

Book ID
119438591
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
137 KB
Volume
148
Category
Article
ISSN
0021-9150

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Evaluation of the poly(ADP-ribose) polym
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## Abstract Amyloid peptide is thought to play a critical role in neuronal death in Alzheimer's disease (AD), most likely through oxidative stress. Free radical‐related injury leads to DNA breaks, which subsequently activates the repair enzyme poly(ADP‐ribose) polymerase‐1 (PARP‐1). In this study,