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Analysis of DNA–protein crosslinking activity of malondialdehyde in vitro

✍ Scribed by Victoria Voitkun; Anatoly Zhitkovich

Book ID
114072474
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
206 KB
Volume
424
Category
Article
ISSN
0027-5107

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✍ F.W. Summerfield; A.L. Tappel 📂 Article 📅 1984 🏛 Elsevier Science 🌐 English ⚖ 619 KB

Malondialdehyde, which is generated by lipid peroxidation, can form DNA-protein and/or interstrand DNA crosslinks. The biological consequences of inaccurate repair of these crosslinks may be severe. The expected levels of crosslinking of DNA in vivo are low, and an extremely sensitive method must be