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Analysis of DNA and single-base mutations using magnetic particles for purification, amplification and DNAzyme detection

โœ Scribed by Willner, Itamar; Cheglakov, Zoya; Weizmann, Yossi; Sharon, Etteri


Book ID
120476056
Publisher
Royal Society of Chemistry
Year
2008
Tongue
English
Weight
266 KB
Volume
133
Category
Article
ISSN
0003-2654

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A number of mitochondrial (mt) point mutations have been associated with inherited disorders. These pathogenic mutations are usually heteroplasmic. Here we describe the identification of three heteroplasmic mtDNA point mutations using the techniques of single stranded conformation polymorphism (SSCP