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Analysis of diethylstilbestrol and its impurities in tablets using reversed-phase high—performance liquid chromatography

✍ Scribed by A.R. Lea; W.J. Kayaba; D.M. Hailey

Publisher
Elsevier Science
Year
1979
Tongue
English
Weight
583 KB
Volume
177
Category
Article
ISSN
1873-3778

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✦ Synopsis

A high-performance liquid chromatographic (HPLC) method is described which is capable of resolving cis-and &ans-diethylstilbestrol (DES), DES mono-and dimethyf ethers and 4,4'-dihydroxystiIbene. The mobile phase and internal standard used stabilise the c&trarrs DES isomer ratio, and the method is capable of quantitating both isomers in dosage forms without derivatisation. Recovery of DES from tablets is quantitative. Results of tablet analyses using this method are compared with those obtained with the official spectrophotometric procedure.

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