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Determination of chlordiazepoxide, its hydrochloride and related impurities in pharmaceutical formulations by reversed-phase high-performance liquid chromatography

โœ Scribed by Stanley E. Roberts; Michael F. Delaney

Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
440 KB
Volume
283
Category
Article
ISSN
1873-3778

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โœฆ Synopsis

A quantitative high-performance liquid chromatographic method using an octadecylsilane column and a methanol-water mobile phase was employed for the determination of chlordiazepoxide, chlordiazepoxide . HCI and related impurities in capsule and tablet preparations. Each component is well separated and directly detected by 254 nm absorption. For chlordiazepoxide and chlordiazepoxide . HCl the coefficient of variation for replicated injections was below 1%. Recovery of authentic samples ranged from 98.4 to 101.6% for both capsule and tablet formulations.

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