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Analysis of complex oligogenic disease

✍ Scribed by Jeffrey R. O'Connell; Sean Davis; Daniel E. Weeks

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 144 KB
Volume: 14
Category: Article
ISSN: 0741-0395
DOI: 10.1002/(sici)1098-2272(1997)14:6<861::aid-gepi50>3.0.co;2-k

No coin nor oath required. For personal study only.

✦ Synopsis

Our analysis of GAW10 problem 2 data set consisted of linear regression analysis followed by linkage analysis. The linear regression analysis allowed some exploration of the relationships between the quantitative variables. Furthermore, it isolated some of the components of certain quantitative variables that were not due to a major locus and facilitated the linkage analysis that followed. For the linkage analysis, we used MAPMAKER/SIBS and the SIBPAL program from S.A.G.E. We found linkage of Q4 to chromosome 8. Analysis using the residuals of Q1 and Q3 showed linkage to chromosomes 5 and 4, respectively.

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