Molecular recognition of different enantiomers of a drug has become of increasing importance in the last decade due to the racemic switch strategy adapted by the pharmaceutical industry. Different analytical techniques to carry out enantioselective analysis of chiral compounds have been suggested in
Analysis of Chiral Drugs with Enantioselective Biosensors. An Overview
β Scribed by Raluca-Ioana Stefan; Jacobus (Koos) F. van Staden; Hassan Y. Aboul-Enein
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 54 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1040-0397
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Several chiral drugs are produced and administered as pure enantiomers, whereas many others, especially of synthetic origin, are used mainly in the form of racemates. The biological and pharmacological activity of chiral compounds depends on their configuration. The racemic drugs may exhibit quite d
Chiral stationary phases (CSPs) are becoming abundant and extensively used in resolution of drug racemates. The polysaccharide-type CSPs namely the cellulose and amylose derivatives are widely used in the resolution and analysis of racemate drugs by high performance liquid chromagraphy (