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Optimization and validation of an enantioselective method for a chiral drug with eight stereo-isomers in capillary electrophoresis

✍ Scribed by M. Ilias Jimidar; Tom Vennekens; Willy Van Ael; Dirk Redlich; Maurits De Smet


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
194 KB
Volume
25
Category
Article
ISSN
0173-0835

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A rapid method for pKa determination of
✍ Yasushi Ishihama; Masahiro Nakamura; Toshinobu Miwa; Takashi Kajima; Naoki Asaka πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 152 KB πŸ‘ 1 views

We developed a rapid screening method for determination of pK(a) of candidate drugs by pressure-assisted capillary electrophoresis (CE) coupled with a photodiode array detector. Application of pressure during CE analysis allowed completion of one CE run in less than 1 min, and the obtained pH-metric