Analysis of CAG/CTG repeat size in chinese subjects with schizophrenia and bipolar affective disorder using the repeat expansion detection method
✍ Scribed by Tao Li; Homero P. Vallada; Xiehe Liu; Tao Xie; Xiangdong Tang; Jinghua Zhao; Michael C. O’Donovan; Robin M. Murray; Pak C. Sham; David A. Collier
- Book ID
- 118511269
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 143 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0006-3223
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The repeat expansion detection (RED) method was described to detect expansions of trinucleotide repeats of unknown chromosomal location. We have improved the RED method by the use of 8-mer oligonucleotides and assessed its usefulness in 30 samples from patients with spinocerebellar ataxia type 1 (SC
## ~ A new class of disease (including Hunting ton disease, Kennedy disease, and spinocerebellar ataxias types 1 and 3) results from abnormal expansions of CAG trinucleotides in the coding regions of genes. In all of these diseases the CAG repeats are thought to be translated into polyglutamine tr