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Analysis of Aβ and neuroinflammation as a function of brain region and disease progression in the TgCRND8 brain

✍ Scribed by Ma, Keran; Mount, Howard T.J.; McLaurin, JoAnne

Book ID
122348226
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
45 KB
Volume
5
Category
Article
ISSN
1552-5260

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## Abstract Therapeutic trials in Huntington's disease (HD) are challenging as clinical progression is slow and variable and reliable biomarkers are lacking. We used magnetic resonance imaging and the brain boundary shift integral to quantify whole‐brain atrophy rates over 1 year in early and prema