antigens) in a solution. The binding of an antigen to an The diffusion-limited kinetics of binding of an analyte in soluantibody-coated surface (or vice versa) is sensed directly tion to a receptor immobilized on a biosensor surface is analyzed and rapidly. There is a need to characterize the reacti
Analysis of analyte–receptor binding kinetics for biosensor applications: an overview of the influence of the fractal dimension on the surface on the binding rate coefficient
✍ Scribed by Anand Ramakrishnan; Ajit Sadana
- Book ID
- 111138465
- Publisher
- Portland Press
- Year
- 1999
- Tongue
- English
- Weight
- 214 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0885-4513
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The diffusion-limited binding kinetics of antigen (analyte) in solution to antibody (receptor) immobilized on a biosensor surface is analyzed within a fractal framework. Most of the data presented are adequately described by a single-fractal analysis. This was indicated by the regression analysis pr
Accurate estimation of biomolecular reaction rates from binding data, when ligands in solution bind to receptors on the surfaces of cells or biosensors, requires an understanding of the contributions of both molecular transport and reaction. Efficient estimation of parameters requires relatively sim