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Analysis of alpha-synuclein (SNCA) mutations in Slovak Parkinson disease patients

✍ Scribed by Bognár, Csaba; Baldovic, Marian; Zatkova, Andrea; Kadasi, Ludovit; Krajcovic, Juraj

Book ID
122793060
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
71 KB
Volume
24
Category
Article
ISSN
0958-1669

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## Abstract Lewy bodies, the pathological hallmark of Parkinson's disease (PD), consist largely of α‐synuclein, a 14.5‐kDa presynaptic neuronal protein implicated in familial PD. An increased copy number and elevated expression of wild‐type α‐synuclein (__SNCA__) has been shown to cause early‐onset