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Analysis of a Theoretical Model Based on Similarity for Studying RNA Base Pairings

✍ Scribed by Patrizia Di Gennaro; Guido Sello; Manuela Termini

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
248 KB
Volume
181
Category
Article
ISSN
0022-5193

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✦ Synopsis

A theoretical model for studying RNA base pairing is presented, based on similarity measures of the bases and corresponding indexes. Similarity calculations are made by evaluating atomic importance in molecules, a method that uses an original method for the calculation of electronic energy. The application of the model to both Watson-Crick and non-Watson-Crick pairings is commented on. Some theoretical considerations concerning the capability of the genetic code to repair dangerous mutations contribute to the ongoing debate.

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## Abstract Based on the concepts of cell and system of graphical representation, a class of 2D graphical representations of RNA secondary structures are given in terms of classifications of bases of nucleic acids. The representations can completely avoid loss of information associated with crossin