Analysis of a balanced translocation on chromosome 1p36 in a neuroblastoma patient
β Scribed by Pauline van der Drift; Alvin Chan; Nadine van Roy; Genevieve Laureys; Andries Westerveld; Frank Speleman; Rogier Versteeg
- Book ID
- 119106307
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 94 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0165-4608
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## Abstract A constitutional chromosome translocation t(1;17)(p36;q12β21) is reported in a boy with neuroblastoma. This is the first description of a cytogenetic abnormality possibly predisposing to the development of neuroblastoma.
Chromosomal band lp36 probably harbours several neuroblastoma suppressor genes. A neuroblastoma patient has been described with a constitutional balanced translocation, t( I ; I7)(p36;q 12-2 I ). Cytogenetically, no loss of chromosomal material was visible. The I p36 translocation breakpoint could t
## Abstract Deletions in the short arm of chromosome 1 (1p36) and __MYCN__ amplification are common in neuroblastoma. Previously we showed evidence of at least two different neuroblastoma tumorβsuppressor loci on 1p. One is associated with __MYCN__ singleβcopy tumors and maps distal on 1p36.3. A se
## Abstract Cytogenetic studies of a rhabdomyosarcoma of mixed embryonal and alveolar histology in an II βmonthβold male revealed a single structural abnormality, t(1;13)(p36;q14). This abnormality may define a subset of patients with a variant of the t(2;13)(q35;q14) translocation frequently seen