Analysis of 8-hydroxy-2′-deoxyguanosine in human urine using hydrophilic interaction chromatography with tandem mass spectrometry
✍ Scribed by Chiemi Hosozumi; Akira Toriba; Thanyarat Chuesaard; Takayuki Kameda; Ning Tang; Kazuichi Hayakawa
- Book ID
- 116620761
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 257 KB
- Volume
- 893-894
- Category
- Article
- ISSN
- 1873-376X
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## Abstract Hydrophilic interaction LC with MS/MS (HILIC‐MS/MS) was described as a rapid, sensitive, and selective method for the quantification of doxazosin in human plasma. Doxazosin and cisapride (internal standard) were extracted from human plasma with ethyl acetate at alkaline pH and analyzed
## Abstract A rapid and high‐throughput method for the determination of urinary levels of the oxidative stress biomarker, 8‐hydroxy‐2′‐deoxyguanosine (8‐OH‐dG), has been developed and validated using liquid chromatography combined with electrospray ionization tandem mass spectrometry (LC‐MS/MS). Th