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Analysis for N2-(pyridyloxobutyl)deoxyguanosine adducts in DNA of tissues exposed to tritium labeled 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine

✍ Scribed by Spratt, Thomas E.; Trushin, Neil; Lin, Dorothy; Hecht, Stephen S.


Book ID
127107535
Publisher
American Chemical Society
Year
1989
Tongue
English
Weight
627 KB
Volume
2
Category
Article
ISSN
0893-228X

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Synthesis of 4- (methylnitrosamino)-1- (
✍ James C. Wiley Jr.; David H. T. Chien; Nancy A. Nungesser; Dorothy Lin; Stephen πŸ“‚ Article πŸ“… 1988 πŸ› John Wiley and Sons 🌐 French βš– 349 KB

The carcinogenic tobacco-specif ic nitrosamines 4- (methylnitrosemino) -1-(3-pyridyl) -1-butanone (NNK) and N'-nitrosonornicotine (NNN), as well as the model compound 4-(carbethoxynitrosamino) -1-(3-pyridyl) -1butanone, were synthesized with tritium at the 5-position of the pyridine ring. In each c