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Analysis and quantitation of a metabolite of doxycycline in mice, rats, and humans by high-performance liquid chromatography

✍ Scribed by R. Böcker

Book ID
108449822
Publisher
Elsevier Science
Year
1983
Weight
540 KB
Volume
274
Category
Article
ISSN
0378-4347

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The antihypertensive agent urapidil (Ebrantil Byk-Gulden, Konstanz) can be reliably quantitated with three metabolites in human serum using high performance liquid chromatography. Serum is alkalinized and extracted with ethyl acetate. The organic phase is back-extracted with diluted acid. An aliquot