Synthesis of a new class of phosphatidylcholine analogues derived from glyceric acid is reported for spectroscopic studies of phospholipases and the conformation of phospholipid side-chains in biological membranes, using fluorescence resonance energy transfer (FRET) techniques.
Analogues of phospholipids: synthesis and biological evaluation of a series of 3-phosphocholine glyceric acid derivatives
β Scribed by U Valcavi; R Aveta; A Brandt; GB Corsi; G Pascucci; F Solinas
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- French
- Weight
- 778 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0223-5234
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Reactions between amide anions and propanal derivatives containing benzolactone components at their 3βpositions produced hemiaminals, which were dehydrated via the corresponding acetates to provide the apicularen A analogues **21**, **29**, **34**, **38**, and **41**. Of these, **21** a
The synthesis and in vitro evaluation of a new series of salvinorin A analogues substituted at the C(2) position with natural amino acids is reported. Compound 12, containing Val, displayed high affinity and full agonist activity at the kappa-opioid receptor. Analogues with bulky and/or aromatic res