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Analogs of tetrahydrofolic acid XXV. 2,4-Diamino-6-phenethylpteridine, an inhibitor of dihydrofolic reductase

โœ Scribed by B. R. Baker; Beng-Thong Ho


Publisher
John Wiley and Sons
Year
1965
Tongue
English
Weight
486 KB
Volume
54
Category
Article
ISSN
0022-3549

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Design, synthesis and biological evaluat
โœ Aleem Gangjee; Hiteshkumar D. Jain; Sherry F. Queener ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 75 KB

Nine novel nonclassical 2,4-diamino-6-methyl-5-thioarylsubstituted-7H-pyrrolo [2,3-d]pyrimidines 2-10 were synthesized as potential inhibitors of dihydrofolate reductase and as antitumor agents. The analogues contain various electron donating and electron withdrawing substituents on the phenylsulfan