๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Analogs of tetrahydrofolic acid. XXI. Synthesis of 6-bromomethyl-5-(p-chlorophenyl)-2,4-diaminopyrimidine and its evaluation as a dihydrofolic reductase inhibitor

โœ Scribed by B. R. Baker; Johannes H. Jordaan


Book ID
112121273
Publisher
Journal of Heterocyclic Chemistry
Year
1965
Tongue
English
Weight
414 KB
Volume
2
Category
Article
ISSN
0022-152X

No coin nor oath required. For personal study only.


๐Ÿ“œ SIMILAR VOLUMES


Design, synthesis and biological evaluat
โœ Aleem Gangjee; Hiteshkumar D. Jain; Sherry F. Queener ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 75 KB

Nine novel nonclassical 2,4-diamino-6-methyl-5-thioarylsubstituted-7H-pyrrolo [2,3-d]pyrimidines 2-10 were synthesized as potential inhibitors of dihydrofolate reductase and as antitumor agents. The analogues contain various electron donating and electron withdrawing substituents on the phenylsulfan

Synthesis and biological evaluation of a
โœ Lynn S. Gossett; Lillian L. Habeck; Susan B. Gates; Sherri L. Andis; John F. Wor ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 170 KB

A novel series of dihydrofolate reductase inhibitors was uncovered during an expansion of the SAR of 5,10-dideazatetrahydrofolic acid, and their biological activity was evaluated. These new analogs do not possess an oxygen at the 4 position and contain a monocyclic pyrimidine ring.