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Analgesics. 2. Selected 5-substituted 5-(1-phenylethyl)barbituric acids

✍ Scribed by Vida, Julius A.; Samour, Carlos M.; O'Dea, Mary H.; Wang, Theodore S. T.; Reinhard, John F.


Book ID
119943662
Publisher
American Chemical Society
Year
1974
Tongue
English
Weight
517 KB
Volume
17
Category
Article
ISSN
0022-2623

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5,5-SUBSTITUTED BARBITURIC ACIDS 1
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Synthesis of 5-(functionalized acyl)-1,3
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## Abstract A sodium derivative of 1,3‐dimefhylbarbituric acid or 1,3‐diethyl‐2‐thiobarbituric acid undergoes an efficient monoacylation at C5 by the reaction with ω‐chloroalkanoyl chloride or diacid dichloride in the presence of pyridine in tetrahydrofuran. A nucleophilic displacement of the chlor