The water soluble fraction (WSF) obtained from a hydroalcohol extract of A. conyzoides, a medicinal plant used in Brazilian folk medicine, was evaluated for possible analgesic and antiinflammatory activities. It was demonstrated that WSF (20-50 mg/kg; i.p.) treatment reduced the articular incapacita
Analgesic, antipyretic and antiinflammatory effects of Achillea ageratum
✍ Scribed by M. D. García; R. Puerta; S. Martínez; M. T. Sáenz
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 135 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0951-418X
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✦ Synopsis
The aqueous and methanol extracts of Achillea ageratum L. (Asteraceae) have been evaluated for analgesic, antipyretic and antiinflammatory properties in mice and rats in several experimental models. The aqueous extract exhibited significant activity in the analgesic and antiinflammatory assays but was unable to reduce hyperthermia. Moreover, the methanol extract exerted effects in three pharmacological actions. The phytochemical investigation of this latter extract revealed the presence of flavonic compounds: luteolin, quercetin and 7-O--luteolin.
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Artemisia ketone, artemisia alcohol, Pcaryophyllene oxide and 1,s-cineole were confirmed as the major components of the volatile oil from Achillea ageratum L. In an antibacterial diffusion assay, the volatile oil showed activity mainly against Gram-positive bacteria Bacillus sp. and Staphylococcus a