๐”– Bobbio Scriptorium
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Analgesic activity of tricyclic antidepressants

โœ Scribed by BS Katharyn Spiegel; Robert Kalb; Dr Gavril W. Pasternak

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
365 KB
Volume
13
Category
Article
ISSN
0364-5134

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## Abstract Activated palladium is used as catalyst for the hydrogenโ€tritium exchange in tricyclic antidepressants. The specific activities obtained are: desipramine: 44.9 Ci/mmol; imipramine: 14.9 Ci/mmol; notriptyline: 2.0 Ci/mmol and amitriptyline: 1.7 Ci/mmol.

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The influence of ageing on serum levels of tertiary tricyclic antidepressants (TCAs) was studied in 385 psychiatric inpatients treated daily with one of three TCAs: 157 patients with amitriptyline (154 f 47 mg, mean dose +SD), 183 with doxepin (177 f 59 mg) and 45 with clomipramine (153 f 51 mg). Th

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We have recently reported that the tricyclic antidepressants (TCAs) imipramine, clomipramine, and citalopram induce apoptosis in human peripheral lymphocytes. This system is well suited for studies on the pathophysiology/physiology of apoptosis regulation. Apoptosis was determined using both DNA gel

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The electron impact and fast-atom bombardment mass spectrometric behaviour of five tricyclic antidepressants (desipramine, imipramine, clomipramine, trimipramine and lofepramine) and of their synthons (iminodibenzyl and 3-chloroiminodibenzyl) have been studied in detail with the aid of metastable-io