Anagrelide and imatinib mesylate combination therapy in patients with chronic myeloproliferative disorders
โ Scribed by Apostolia M. Tsimberidou; Dawn E. Colburn; Mary Alma Welch; Jorge E. Cortes; Srdan Verstovsek; Susan M. O'Brien; Maher Albitar; Hagop M. Kantarjian; Francis J. Giles
- Book ID
- 105991820
- Publisher
- Springer
- Year
- 2003
- Tongue
- English
- Weight
- 187 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0344-5704
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## Abstract ## BACKGROUND Imatinib mesylate is a selective tyrosine kinase inhibitor of cโabl, bcr/abl, cโkit, and plateletโderived growth factorโreceptor (PDGFโR). cโkit is expressed in most patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) and PDGF has been implicated
## Abstract ## BACKGROUND Reticulinโstained bone marrow fibrosis is associated with a poor prognosis in patients with chronic myelogenous leukemia (CML). Resolution of fibrosis with therapy may improve patient outcome. ## METHODS The effect of imatinib therapy on bone marrow fibrosis was evaluat
## Abstract ## BACKGROUND Imatinib mesylate induces high rates of hematologic and cytogenetic response in patients with chronic myelogenous leukemia (CML). During therapy with imatinib, up to 45% of patients with CML reportedly experience myelosuppression โฅ Grade 3, requiring interruption of thera